When choosing breathable waders with boots, it's essential to consider factors such as the water temperature, depth, and terrain you'll be wading in. For colder conditions, neoprene waders may offer better insulation and warmth, while Gore-Tex waders are more breathable and lightweight for warmer weather. Additionally, the fit and sizing of the waders are crucial for comfort and mobility, so be sure to get the right size for a snug and secure fit.