Pill capsule is one of the most important ways for people to take oral drugs over the last hundred years, and gelatin becomes the first choice for capsule materials because of its low price and stable chemical and physical properties. As the wide usage of the gelatin, some of its problems were gradually revealed. On the one hand, because early gelatin is often made from the bone and skin of cattle and pigs, many diseases are thought to be easily transmitted by gelatin capsule, such as mad cow disease (bovine spongiform encephalopathy). And these ingredients may be unacceptable to vegetarians, Jews, Islamists or Hindus. On the other hand, the development of various New Chemical Entity causes more requirements for using gelatin capsules. For example, some substances containing aldehyde groups may cause a cross-linking reaction of gelatin, and with strong reducing substances, the gelatin will cause Mailard Reaction, and so on. Therefore, many experts started to look for a new alternative for capsule material, which would be safer and healthier. HPMC (HYDROXYPROPYL METHYLCELLULOSE) is one of the suitable alternatives, and then it comes out HPMC capsule.